Table 2. Statistical analysis of relapse in follicular lymphoma patients whose miR-92a levels were determined at complete response and complete response uncertain phase.
univariate | |||||
Factors at diagnosis | No. (n = 19) | Relpased (n = 6) | P value | odds ratio | 95% CI |
Sex | |||||
male | 10 | 3 | .876 | 0.857 | 0.1235 to 5.947 |
female | 9 | 3 | |||
Age | |||||
≥60 years | 9 | 4 | .252 | 3.2 | 0.4192 to 24.43 |
<60 years | 10 | 2 | |||
LDH | |||||
Elevated | 2 | 0 | .31 | 0.354 | 0.01463 to 8.559 |
Normal | 17 | 6 | |||
Hemoglobin | |||||
≤120 g/L | 3 | 2 | .154 | 6 | 0.4220 to 85.30 |
≥120 g/L | 16 | 4 | |||
Ann Arbor stage | |||||
III+IV | 13 | 5 | .342 | 3.125 | 0.2776 to 35.18 |
I+II | 6 | 1 | |||
No. of nodal area involved | |||||
>4 | 6 | 2 | .911 | 1.125 | 0.1425 to 8.884 |
≤4 | 13 | 4 | |||
Bone marrow invasion | |||||
Yes | 8 | 3 | .636 | 1.6 | 0.2271 to 11.27 |
No | 11 | 3 | |||
β2-microglobulin elevation* | |||||
Yes | 8 | 3 | .41 | 2.4 | 0.2910 to 19.79 |
No | 10 | 2 | |||
FLIPI | |||||
High | 3 | 1 | |||
Intermediate | 8 | 3 | .863 | ||
Low | 8 | 2 | |||
FLIPI-2* | |||||
High | 4 | 3 | |||
Intermediate | 11 | 2 | .047 | ||
Low | 3 | 0 | |||
Plasma miR-92a | |||||
Low (<0.2165) | 8 | 5 | .013 | 16.67 | 1.361 to 204.2 |
Normal (≥0.2165) | 11 | 1 |
Abbreviations: CI, confidence interval; LDH, lactate dehydrogenase; FLIPI, Follicular Lymphoma International Prognostic Index.
*Data from 1 patient were missing.