Skip to main content
. 2011 Feb 24;6(2):e17240. doi: 10.1371/journal.pone.0017240

Figure 6. Effect of S14 on in vivo inflammation and rotational behavior.

Figure 6

Lipopolysaccharide (LPS, 10 µg) or vehicle was injected unilaterally into the adult substantia nigra pars compacta (SNpc) of adult rats. A group of animals also received S14 (20 nmol) or BRL50481 (BRL, 60 nmol) together with LPS. (A) After 72 h the brains were removed and tissue sections were processed for CD11b (OX-42) immunoreactivity lo label activated microglia. Scale bars, 500 µm. Insets scale bars, 100 µm. Quantification of the reactive cells is expressed as the mean ± SD, from three different experiments, four animals/experiment/experimental group, and five independent sections per animal. ***p<0.001 versus LPS-treated animals. (B) Behavioral analysis. Three weeks after treatment apomorphine-induced rotations were analyzed in control, LPS-injected, and LPS+S14-injected rats. Values represent the means ± SD from three different experiments. ***p<0.001, versus LPS-injected animals.