Table 2. Associations between selected SNPs and prostate cancer risk.
SNP | Pos | Chr | Gene | N Cases | N Controls | MAF Cases | MAF Controls | OR Het | OR Hom | OR allele | P-value | Ref |
rs721048 | 62,985,235 | 2 | EHBP1 | 10160 | 10474 | 0.19 | 0.18 | 1.12 (1.06–1.19) | 1.22 (1.04–1.42) | 1.11 (1.06–1.17) | 2.47E-05 | 1 |
rs1465618 | 43,407,453 | 2 | THADA | 9758 | 9627 | 0.23 | 0.21 | 1.09 (1.00–1.19) | 1.18 (0.97–1.43) | 1.12 (1.06–1.17) | 1.02E-05 | 12 |
rs12621278 | 173,019,799 | 2 | ITGA6 | 9822 | 9667 | 0.05 | 0.06 | 0.88 (0.76–1.02) | 0.32 (0.13–0.83) | 0.86 (0.78–0.94) | 0.0010 | 12 |
rs2660753 | 87,193,364 | 3 | – | 10000 | 10502 | 0.12 | 0.11 | 1.12 (1.05–1.20) | 1.32 (1.05–1.66) | 1.13 (1.06–1.20) | 9.18E-05 | 2 |
rs4857841 | 129,529,333 | 3 | EEFSEC | 9589 | 10103 | 0.30 | 0.28 | 1.13 (1.07–1.20) | 1.28 (1.15–1.42) | 1.13 (1.08–1.18) | 2.32E-08 | 3 |
rs17021918 | 95,781,900 | 4 | PDLIM5 | 9791 | 9702 | 0.32 | 0.34 | 0.88 (0.81–0.96) | 0.84 (0.73–0.97) | 0.92 (0.88–0.96) | 5.35E-05 | 12 |
rs12500426 | 95,733,632 | 4 | PDLIM5 | 9784 | 9643 | 0.48 | 0.47 | 1.07 (0.97–1.19) | 1.14 (1.02–1.29) | 1.07 (1.02–1.11) | 0.0021 | 12 |
rs7679673 | 106,280,983 | 4 | TET2 | 9772 | 9613 | 0.39 | 0.42 | 0.82 (0.74–0.89) | 0.74 (0.65–0.85) | 0.88 (0.84–0.92) | 6.74E-10 | 12 |
rs9364554 | 160,753,654 | 6 | SLC22A3 | 9994 | 10464 | 0.29 | 0.28 | 1.08 (1.02–1.15) | 1.15 (1.04–1.27) | 1.08 (1.03–1.12) | 0.00086 | 2 |
rs10486567 | 27,943,088 | 7 | JAZF1 | 10242 | 10618 | 0.21 | 0.24 | 0.82 (0.78–0.87) | 0.73 (0.64–0.83) | 0.84 (0.80–0.88) | 7.05E-14 | 4 |
rs6465657 | 97,654,263 | 7 | LMTK2 | 9994 | 10465 | 0.48 | 0.46 | 1.13 (1.06–1.21) | 1.23 (1.14–1.33) | 1.11 (1.07–1.16) | 1.52E-07 | 2 |
rs1512268 | 23,582,408 | 8 | NKX3–1 | 9849 | 9732 | 0.46 | 0.44 | 1.12 (1.02–1.23) | 1.28 (1.14–1.44) | 1.11 (1.06–1.15) | 5.52E-07 | 12 |
rs2928679 | 23,494,920 | 8 | SLC25A37 | 9845 | 9697 | 0.46 | 0.44 | 1.01 (0.91–1.11) | 1.16 (1.03–1.30) | 1.06 (1.02–1.11) | 0.0036 | 12 |
rs4961199 | 87,650,060 | 8 | CPNE3,CNGB3 | 9184 | 9147 | 0.17 | 0.16 | 1.03 (0.97–1.10) | 1.36 (1.13–1.64) | 1.07 (1.02–1.14) | 0.012 | 4 |
rs1016343 | 128,162,479 | 8 | – | 9636 | 10116 | 0.24 | 0.20 | 1.22 (1.15–1.30) | 1.64 (1.44–1.88) | 1.25 (1.19–1.31) | 1.54E-19 | 2 |
rs7841060 | 128,165,659 | 8 | – | 9341 | 9859 | 0.24 | 0.20 | 1.22 (1.15–1.30) | 1.63 (1.42–1.86) | 1.24 (1.18–1.31) | 1.43E-18 | 3 |
rs16901979 | 128,194,098 | 8 | – | 9120 | 9079 | 0.05 | 0.03 | 1.41 (1.26–1.58) | 3.02 (1.47–6.23) | 1.44 (1.29–1.60) | 1.55E-11 | 5 |
rs620861 | 128,404,855 | 8 | – | 9097 | 9611 | 0.34 | 0.37 | 0.86 (0.81–0.92) | 0.75 (0.68–0.82) | 0.87 (0.83–0.90) | 3.59E-11 | 3 |
rs6983267 | 128,482,487 | 8 | – | 10186 | 10521 | 0.44 | 0.49 | 0.82 (0.77–0.87) | 0.66 (0.61–0.71) | 0.81 (0.78–0.84) | 6.62E-26 | 4 |
rs1447295 | 128,554,220 | 8 | – | 9640 | 10098 | 0.14 | 0.10 | 1.38 (1.29–1.48) | 1.94 (1.53–2.47) | 1.38 (1.30–1.47) | 8.06E-25 | 6 |
rs4242382 | 128,586,755 | 8 | – | 10296 | 10630 | 0.14 | 0.10 | 1.41 (1.31–1.51) | 1.95 (1.55–2.47) | 1.40 (1.32–1.49) | 4.17E-28 | 4 |
rs7837688 | 128,608,542 | 8 | – | 9624 | 10133 | 0.13 | 0.10 | 1.34 (1.25–1.44) | 1.96 (1.54–2.50) | 1.36 (1.27–1.44) | 6.70E-22 | 7 |
rs16902094 | 128,389,528 | 8 | 8407 | 8378 | 0.18 | 0.16 | 1.23 (1.11–1.36) | 1.10 (0.81–1.48) | 1.18 (1.11–1.25) | 4.78E-08 | 13 | |
rs1571801 | 123,467,194 | 9 | – | 9961 | 9833 | 0.27 | 0.25 | 1.08 (1.02–1.15) | 1.11 (0.99–1.24) | 1.07 (1.02–1.12) | 0.0049 | 8 |
rs10993994 | 51,219,502 | 10 | MSMB | 9982 | 10493 | 0.44 | 0.39 | 1.20 (1.12–1.27) | 1.53 (1.41–1.66) | 1.23 (1.18–1.28) | 5.95E-25 | 4 |
rs4962416 | 126,686,862 | 10 | CTBP2 | 10020 | 10348 | 0.29 | 0.27 | 1.07 (1.01–1.13) | 1.23 (1.11–1.37) | 1.09 (1.05–1.14) | 7.92E-05 | 4 |
rs7127900 | 2190150 | 11 | 9793 | 9694 | 0.22 | 0.20 | 1.20 (1.09–1.31) | 1.62 (1.31–2.00) | 1.14 (1.09–1.20) | 2.01E-07 | 12 | |
rs12418451 | 68,691,995 | 11 | – | 9641 | 10129 | 0.31 | 0.29 | 1.12 (1.05–1.19) | 1.27 (1.15–1.41) | 1.12 (1.08–1.17) | 1.42E-07 | 9 |
rs7931342 | 68,751,073 | 11 | – | 9765 | 10226 | 0.45 | 0.49 | 0.86 (0.81–0.92) | 0.71 (0.66–0.77) | 0.85 (0.81–0.88) | 1.11E-16 | 2 |
rs10896449 | 68,751,243 | 11 | – | 10122 | 10504 | 0.45 | 0.50 | 0.86 (0.80–0.91) | 0.70 (0.65–0.76) | 0.84 (0.81–0.87) | 3.58E-19 | 4 |
rs11649743 | 33,149,092 | 17 | TCF2 | 10184 | 10538 | 0.17 | 0.19 | 0.87 (0.82–0.92) | 0.76 (0.65–0.89) | 0.87 (0.83–0.92) | 7.55E-08 | 10 |
rs4430796 | 33,172,153 | 17 | TCF2 | 9984 | 9785 | 0.44 | 0.49 | 0.80 (0.75–0.85) | 0.64 (0.59–0.69) | 0.80 (0.77–0.83) | 2.09E-28 | 11 |
rs7501939 | 33,175,269 | 17 | TCF2 | 9557 | 10082 | 0.36 | 0.40 | 0.80 (0.76–0.86) | 0.69 (0.63–0.75) | 0.82 (0.79–0.86) | 2.78E-20 | 2 |
rs1859962 | 66,620,348 | 17 | – | 10202 | 10547 | 0.53 | 0.48 | 1.23 (1.15–1.32) | 1.41 (1.31–1.53) | 1.19 (1.14–1.24) | 2.74E-18 | 11 |
rs266849 | 56,040,902 | 19 | KLK3 | 10015 | 10348 | 0.18 | 0.19 | 0.91 (0.86–0.97) | 0.94 (0.81–1.09) | 0.93 (0.89–0.98) | 0.0085 | 2 |
rs2735839 | 56,056,435 | 19 | KLK3 | 9862 | 10366 | 0.13 | 0.15 | 0.90 (0.84–0.96) | 0.67 (0.54–0.82) | 0.87 (0.82–0.92) | 3.05E-06 | 2 |
rs5759167 | 41,830,156 | 22 | BIK | 9843 | 9729 | 0.47 | 0.50 | 0.83 (0.75–0.91) | 0.70 (0.62–0.79) | 0.87 (0.83–0.90) | 1.30E-12 | 12 |
rs5945572 | 51,246,423 | X | NUDT11 | 9338 | 9830 | 0.40 | 0.35 | 1.22 (1.15–1.29) | 6.17E-11 | 1 | ||
rs5945619 | 51,258,412 | X | NUDT11 | 9999 | 10456 | 0.41 | 0.36 | 1.23 (1.16–1.31) | 8.27E-13 | 2 |
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