Table 3. Associations between selected SNPs and Gleason grade and Stage.
Odds Ratio1 (95% CI) | Odds Ratio1 (95% CI) | |||||
SNP | Gleason <8 | Gleason 8–10 | P case-only test | Stage AB | StageCD | P case-only test |
rs721048 | 1.13 (1.07–1.20) | 1.07 (0.96–1.19) | 0.30 | 1.13 (1.07–1.20) | 1.09 (0.99–1.19) | 0.5 |
rs1465618 | 1.10 (1.05–1.16) | 1.17 (1.06–1.30) | 0.15 | 1.13 (1.07–1.19) | 1.07 (0.97–1.17) | 0.34 |
rs12621278 | 0.87 (0.79–0.96) | 0.77 (0.62–0.95) | 0.27 | 0.87 (0.78–0.96) | 0.85 (0.71–1.02) | 0.86 |
rs2660753 | 1.10 (1.03–1.18) | 1.11 (0.98–1.26) | 0.81 | 1.13 (1.05–1.21) | 1.14 (1.01–1.27) | 0.82 |
rs4857841 | 1.13 (1.07–1.18) | 1.15 (1.05–1.26) | 0.54 | 1.14 (1.09–1.20) | 1.15 (1.06–1.25) | 0.53 |
rs17021918 | 0.91 (0.87–0.95) | 0.96 (0.88–1.05) | 0.22 | 0.89 (0.58–0.93) | 1.01 (0.93–1.09) | 0.004 |
rs12500426 | 1.07 (1.03–1.12) | 0.99 (0.91–1.08) | 0.09 | 1.08 (1.04–1.13) | 0.97 (0.89–1.04) | 0.007 |
rs7679673 | 0.88 (0.84–0.92) | 0.86 (0.79–0.94) | 0.63 | 0.88 (0.84–0.92) | 0.85 (0.78–0.92) | 0.49 |
rs9364554 | 1.10 (1.05–1.15) | 1.03 (0.94–1.13) | 0.28 | 1.07 (1.02–1.12) | 1.13 (1.04–1.22) | 0.30 |
rs10486567 | 0.83 (0.78–0.88) | 0.93 (0.83–1.05) | 0.06 | 0.81 (0.77–0.85) | 0.91 (0.84–1.00) | 0.02 |
rs6465657 | 1.10 (1.05–1.15) | 1.09 (1.01–1.18) | 0.80 | 1.12 (1.07–1.17) | 1.03 (0.96–1.11) | 0.02 |
rs1512268 | 1.11 (1.06–1.16) | 1.02 (0.94–1.11) | 0.08 | 1.12 (1.07–1.17) | 1.05 (0.97–1.13) | 0.05 |
rs2928679 | 1.07 (1.03–1.12) | 1.09 (1.00–1.19) | 0.81 | 1.08 (1.03–1.12) | 1.05 (0.97–1.14) | 0.78 |
rs4961199 | 1.10 (1.04–1.17) | 1.08 (0.97–1.22) | 0.82 | 1.08 (1.01–1.15) | 1.10 (0.99–1.22) | 0.70 |
rs1016343 | 1.24 (1.17–1.31) | 1.31 (1.18–1.45) | 0.33 | 1.26 (1.19–1.33) | 1.25 (1.15–1.37) | 0.92 |
rs7841060 | 1.23 (1.17–1.30) | 1.31 (1.18–1.45) | 0.32 | 1.26 (1.19–1.33) | 1.24 (1.13–1.36) | 0.82 |
rs16901979 | 1.43 (1.27–1.60) | 1.39 (1.12–1.72) | 0.91 | 1.40 (1.24–1.58) | 1.55 (1.29–1.86) | 0.33 |
rs620861 | 0.85 (0.81–0.89) | 0.89 (0.81–0.97) | 0.34 | 0.87 (0.83–0.91) | 0.82 (0.75–0.89) | 0.37 |
rs6983267 | 0.80 (0.77–0.84) | 0.84 (0.77–0.91) | 0.62 | 0.82 (0.78–0.85) | 0.82 (0.76–0.89) | 0.54 |
rs1447295 | 1.41 (1.32–1.51) | 1.31 (1.16–1.49) | 0.35 | 1.36 (1.27–1.46) | 1.51 (1.36–1.68) | 0.06 |
rs4242382 | 1.43 (1.34–1.53) | 1.38 (1.22–1.55) | 0.73 | 1.39 (1.30–1.49) | 1.49 (1.34–1.66) | 0.24 |
rs7837688 | 1.39 (1.30–1.49) | 1.33 (1.18–1.51) | 0.72 | 1.34 (1.25–1.44) | 1.47 (1.32–1.64) | 0.09 |
rs16902094 | 1.19 (1.12–1.27) | 1.07 (0.94–1.21) | 0.08 | 1.18 (1.10–1.26) | 1.18 (1.06–1.31) | 0.74 |
rs1571801 | 1.07 (1.02–1.13) | 1.10 (1.01–1.21) | 0.50 | 1.07 (1.02–1.13) | 1.09 (1.00–1.19) | 0.62 |
rs10993994 | 1.23 (1.18–1.29) | 1.21 (1.12–1.32) | 0.94 | 1.25 (1.19–1.30) | 1.20 (1.11–1.29) | 0.29 |
rs4962416 | 1.10 (1.05–1.16) | 1.09 (1.00–1.20) | 0.93 | 1.10 (1.05–1.15) | 1.10 (1.01–1.19) | 0.88 |
rs7127900 | 1.14 (1.08–1.21) | 1.05 (0.95–1.17) | 0.14 | 1.14 (1.08–1.20) | 1.16 (1.06–1.28) | 0.81 |
rs12418451 | 1.11 (1.06–1.17) | 1.20 (1.10–1.31) | 0.09 | 1.14 (1.08–1.19) | 1.06 (0.97–1.15) | 0.14 |
rs7931342 | 0.86 (0.82–0.90) | 0.81 (0.75–0.88) | 0.21 | 0.85 (0.81–0.89) | 0.88 (0.81–0.94) | 0.33 |
rs10896449 | 0.85 (0.82–0.89) | 0.80 (0.74–0.87) | 0.13 | 0.84 (0.80–0.87) | 0.86 (0.80–0.93) | 0.34 |
rs11649743 | 0.88 (0.83–0.93) | 0.93 (0.84–1.03) | 0.40 | 0.89 (0.84–0.94) | 0.84 (0.76–0.93) | 0.21 |
rs4430796 | 0.78 (0.75–0.81) | 0.84 (0.77–0.91) | 0.05 | 0.81 (0.77–0.84) | 0.78 (0.73–0.85) | 0.47 |
rs7501939 | 0.81 (0.77–0.85) | 0.85 (0.77–0.92) | 0.30 | 0.83 (0.80–0.87) | 0.80 (0.74–0.86) | 0.28 |
rs1859962 | 1.20 (1.15–1.25) | 1.17 (1.08–1.27) | 0.70 | 1.18 (1.13–1.24) | 1.22 (1.13–1.31) | 0.58 |
rs266849 | 0.91 (0.86–0.96) | 1.10 (1.00–1.22) | 0.0004 | 0.92 (0.87–0.97) | 0.98 (0.89–1.08) | 0.18 |
rs2735839 | 0.84 (0.79–0.89) | 1.07 (0.95–1.19) | 0.0001 | 0.85 (0.80–0.91) | 0.92 (0.83–1.03) | 0.17 |
rs5759167 | 0.87 (0.83–0.91) | 0.85 (0.78–0.93) | 0.59 | 0.88 (0.84–0.92) | 0.82 (0.76–0.89) | 0.11 |
rs5945572 | 1.24 (1.16–1.32) | 1.20 (1.06–1.36) | 0.56 | 1.22 (1.14–1.31) | 1.27 (1.14–1.42) | 0.57 |
rs5945619 | 1.26 (1.19–1.34) | 1.19 (1.05–1.34) | 0.26 | 1.22 (1.14–1.30) | 1.33 (1.20–1.28) | 0.16 |
Odds ratios were estimated using multinomial regression.