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. Author manuscript; available in PMC: 2012 Jan 1.

Published in final edited form as: J Neuropathol Exp Neurol. 2011 Jan;70(1):51–62. doi: 10.1097/NEN.0b013e3182032d37

Microglia ablation at 3 months of age reduces optic glioma proliferation. (A, B) Treatment of Nf1^+/-GFAPCKO-TK mice (n = 7) with ganciclovir (GCV) at 3 months of age reduces the number of Iba1-positive cells by 49% (p = 0.0280) and results in a 94% decrease in the number of Ki-67-positive cells in the optic nerve (p = 0.0118) vs. Nf1^+/-GFAPCKO-TK mice treated with vehicle (n = 7). (C) GCV treatment did not affect endothelial cell numbers, as assessed by CD34 immunohistochemistry (p = 0.2864).

Microglia ablation at 3 months of age reduces optic glioma proliferation. (A, B) Treatment of Nf1^+/-GFAPCKO-TK mice (n = 7) with ganciclovir (GCV) at 3 months of age reduces the number of Iba1-positive cells by 49% (p = 0.0280) and results in a 94% decrease in the number of Ki-67-positive cells in the optic nerve (p = 0.0118) vs. Nf1^+/-GFAPCKO-TK mice treated with vehicle (n = 7). (C) GCV treatment did not affect endothelial cell numbers, as assessed by CD34 immunohistochemistry (p = 0.2864).