Figure 2A: Meth decreases the expression of costimulatory molecule, CD83 on MDC. Normal MDC cultures (~ 5×105 cell/ml) were treated with Meth for 24 hr following which FACS analysis was done to determine the percentage of MDC expressing costimulatory molecule, CD83. Statistical significance was calculated by Students' ‘t’-test (n=3).
Figure 2B: Meth inhibits MDC maturation by decreasing the expression of CCR7. MDC (~ 5×105 cell/ml) were treated with Meth for 24 hr following which FACS analysis was done to determine the percentage of cells expressing CCR7. Statistical significance was calculated by Students' ‘t’-test (n=3).