Table 7.
Immune function means, SD, minima, and maxima by treatment arm and measurement occasion
| Outcome | Day |
100 mg |
1000 mg |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| N | Mean | SD | Min | Max | N | Mean | SD | Min | Max | ||
| T cells | 1 | 5 | 2.01 | 0.32 | 1.77 | 2.55 | 5 | 1.93 | 0.45 | 1.58 | 2.55 |
| 3 | 5 | 2.19 | 0.36 | 1.83 | 2.73 | 5 | 1.96 | 0.35 | 1.45 | 2.31 | |
| 28 | 5 | 1.93 | 0.35 | 1.63 | 2.49 | 5 | 1.90 | 0.40 | 1.47 | 2.49 | |
| B cells CD19 | 1 | 5 | 0.24 | 0.08 | 0.18 | 0.38 | 5 | 0.25 | 0.08 | 0.16 | 0.38 |
| 3 | 5 | 0.24 | 0.09 | 0.13 | 0.33 | 5 | 0.23 | 0.06 | 0.17 | 0.33 | |
| 28 | 5 | 0.18 | 0.08 | 0.10 | 0.31 | 5 | 0.20 | 0.06 | 0.16 | 0.31 | |
| Helper T cells | 1 | 5 | 1.30 | 0.19 | 0.99 | 1.46 | 5 | 1.28 | 0.25 | 0.92 | 1.57 |
| 3 | 5 | 1.44 | 0.43 | 0.88 | 1.93 | 5 | 1.30 | 0.20 | 1.02 | 1.54 | |
| 28 | 5 | 1.28 | 0.24 | 0.86 | 1.41 | 5 | 1.28 | 0.18 | 0.97 | 1.41 | |
| Cytotoxic T cells | 1 | 5 | 0.71 | 0.33 | 0.41 | 1.19 | 5 | 0.66 | 0.31 | 0.41 | 1.19 |
| 3 | 5 | 0.76 | 0.26 | 0.45 | 1.10 | 5 | 0.71 | 0.24 | 0.45 | 1.10 | |
| 28 | 5 | 0.66 | 0.28 | 0.41 | 1.11 | 5 | 0.65 | 0.28 | 0.41 | 1.11 | |
| Natural killer cells | 1 | 5 | 0.28 | 0.10 | 0.16 | 0.39 | 5 | 0.24 | 0.11 | 0.06 | 0.33 |
| 3 | 5 | 0.40 | 0.18 | 0.19 | 0.67 | 5 | 0.35 | 0.21 | 0.08 | 0.67 | |
| 28 | 5 | 0.26 | 0.06 | 0.20 | 0.33 | 5 | 0.24 | 0.09 | 0.08 | 0.32 | |
| Total T cells | 1 | 5 | 32.32 | 9.19 | 18.80 | 42.30 | 5 | 30.76 | 5.27 | 24.20 | 38.70 |
| 3 | 5 | 28.96 | 9.41 | 17.10 | 40.60 | 5 | 29.04 | 8.51 | 20.50 | 41.10 | |
| 28 | 5 | 34.56 | 10.47 | 16.70 | 44.00 | 5 | 33.56 | 6.19 | 28.30 | 44.00 | |
| Activation CD4 | 1 | 5 | 30.16 | 9.11 | 17.10 | 40.30 | 5 | 26.06 | 6.01 | 17.70 | 34.50 |
| 3 | 5 | 27.00 | 9.38 | 15.20 | 38.70 | 5 | 24.64 | 8.84 | 15.00 | 38.70 | |
| 28 | 5 | 31.34 | 9.77 | 15.40 | 40.50 | 5 | 30.30 | 6.36 | 23.10 | 40.50 | |
| Activation CD8 | 1 | 5 | 35.48 | 11.38 | 18.30 | 46.40 | 5 | 35.68 | 4.51 | 30.40 | 41.60 |
| 3 | 5 | 29.08 | 11.37 | 14.80 | 42.70 | 5 | 31.22 | 9.17 | 20.10 | 40.40 | |
| 28 | 5 | 39.42 | 13.53 | 16.20 | 51.60 | 5 | 36.56 | 9.07 | 29.50 | 51.60 | |
| Granulocyte | 1 | 5 | 50.92 | 4.43 | 44.71 | 55.62 | 5 | 59.87 | 5.73 | 49.83 | 64.38 |
| Phagocytosis | 3 | 5 | 52.46 | 8.27 | 41.64 | 63.16 | 5 | 63.15 | 9.27 | 47.18 | 69.11 |
| 28 | 5 | 55.85 | 7.66 | 45.13 | 65.10 | 5 | 62.52 | 4.71 | 55.75 | 67.76 | |
| Monocyte | 1 | 5 | 37.79 | 5.57 | 31.02 | 44.58 | 5 | 45.53 | 6.98 | 36.35 | 53.08 |
| Phagocytosis | 3 | 5 | 42.74 | 6.73 | 33.52 | 50.91 | 5 | 48.27 | 4.64 | 40.00 | 50.93 |
| 28 | 5 | 50.40 | 7.18 | 41.05 | 59.97 | 5 | 51.99 | 4.76 | 45.02 | 56.96 | |
| IFN-gamma | 1 | 5 | 9862 | 8943 | 0 | 19,094 | 5 | 1412 | 898 | 292 | 2490 |
| 3 | 5 | 8302 | 6829 | 0 | 15,336 | 5 | 1641 | 623 | 732 | 2239 | |
| 28 | 5 | 7327 | 7247 | 0 | 15,336 | 5 | 1258 | 574 | 314 | 1777 | |
| IL-6 | 1 | 5 | 20,955 | 5388 | 17,541 | 30,374 | 5 | 23,509 | 6858 | 15,476 | 31,678 |
| 3 | 5 | 22,108 | 6696 | 15,476 | 33,042 | 5 | 24,195 | 4894 | 20,105 | 32,695 | |
| 28 | 5 | 16,022 | 5181 | 10,955 | 22,957 | 5 | 18,864 | 5073 | 13,805 | 27,079 | |
| TNF-alpha | 1 | 5 | 3282 | 1041 | 1832 | 4343 | 5 | 2564 | 1214 | 919 | 4242 |
| 3 | 5 | 6150 | 3413 | 1832 | 11,221 | 5 | 2186 | 1380 | 742 | 4067 | |
| 28 | 5 | 4337 | 1998 | 1409 | 6433 | 5 | 4435 | 1245 | 2924 | 6373 | |
| IL-10 | 1 | 5 | 40.40 | 21.10 | 18.00 | 66.00 | 5 | 41.20 | 8.47 | 28.00 | 49.00 |
| 3 | 5 | 47.80 | 17.54 | 28.00 | 73.00 | 5 | 49.00 | 35.43 | 18.00 | 105.00 | |
| 28 | 5 | 29.20 | 20.56 | 0.00 | 57.00 | 5 | 29.80 | 23.69 | 0.00 | 64.00 | |
| IL-2 | 1 | 5 | 25.80 | 15.35 | 0.00 | 41.00 | 5 | 20.20 | 11.45 | 0.00 | 28.00 |
| 3 | 5 | 28.00 | 3.74 | 22.00 | 32.00 | 5 | 27.40 | 9.48 | 16.00 | 41.00 | |
| 28 | 5 | 20.00 | 19.39 | 0.00 | 52.00 | 5 | 15.20 | 10.80 | 0.00 | 30.00 | |
| IL-4 | 1 | 5 | 0.00 | 0.00 | 0.00 | 0.00 | 5 | 0.00 | 0.00 | 0.00 | 0.00 |
| 3 | 5 | 20.60 | 29.00 | 0.00 | 61.00 | 5 | 8.00 | 17.89 | 0.00 | 40.00 | |
| 28 | 5 | 11.40 | 25.49 | 0.00 | 57.00 | 5 | 14.40 | 13.16 | 0.00 | 25.00 | |
Abbreviations: IFN, interferon; IL, interleukin; max, maximum; min, minimum; SD, standard deviation; TNF, tumor necrosis factor.