Table 2.
CagA seropositivity and risk of gastric cancer irrespective of Helicobacter pylori status.
| Author (year) | Country | Method | Controls |
Gastric cancer |
OR | 95% CI | Ref. | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Positive | Total | Prevalence (%) | Positive | Total | Prevalence (%) | ||||||
| Mitchell et al. (1996) | China | Immunoblot | 30 | 35 | 85.7 | 40 | 48 | 83.3 | 0.83 | 0.25–2.80 | [39] |
| Shimoyama et al. (1996) | Japan | ELISA | 36 | 81 | 44.4 | 49 | 81 | 60.5 | 1.91 | 1.02–3.58 | [31] |
| Kikuchi et al. (1999) | Japan | ELISA | 50 | 201 | 24.9 | 58 | 101 | 57.4 | 4.07 | 2.45–6.77 | [33] |
| Maeda et al. (2000) | Japan | ELISA | 44 | 80 | 55.0 | 74 | 80 | 92.5 | 10.09 | 3.94–25.87 | [38] |
| Limburg et al. (2001) | China | ELISA | 56 | 192 | 29.2 | 69 | 181 | 38.1 | 1.50 | 0.97–2.31 | [34] |
| Sasazuki et al. (2006) | Japan | ELISA | 358 | 511 | 70.1 | 390 | 511 | 76.3 | 1.38 | 1.04–1.82 | [35] |
| Gwack et al. (2006) | Korea | Immunoblot | 337 | 400 | 84.3 | 90 | 100 | 90.0 | 1.68 | 0.83–3.41 | [36] |
| Suzuki et al. (2007) | Japan | ELISA | 684 | 1042 | 65.6 | 249 | 321 | 77.6 | 1.81 | 1.35–2.42 | [37] |
| Overall | 1.81 | 1.30–2.11 | |||||||||
CagA: Cytotokine-associated gene A protein; CI: Confidence interval; ELISA: Enzyme-linked immunosorbent assay; OR: Odds ratio.