Significant negative effect of the CGG repeat size on the grey matter (GM) density in the FMR1 premutation carriers. (A) Clusters of voxels in the dorsal medial regions showing significant negative correlation with the CGG repeat size. The blue circles indicate the largest cluster in the supplementary motor area in the sagittal, coronal and axial views. (B) The plot of CGG repeat size and the grey matter density at a voxel of the highest t-value in the supplementary motor area (x, y, z = 5, −6, 59). The y-axis represents the residual from a linear regression of age over the modulated grey matter density at this coordinate.