Table 3.
Group comparisons of age-adjusted grey matter density in the cerebellar subregions
| Region | Healthy controls | PFX+ | PFX− | F-test |
|---|---|---|---|---|
| Vermis | ||||
| Lobule I/II*,*** | 3.48 ± 1.10 | −2.91 ± 1.19 | 0.59 ± 1.08 | F = 8.42, P < 0.001 |
| Lobule III* | 3.32 ± 1.04 | −3.26 ± 1.07 | 0.09 ± 1.08 | F = 10.09, P < 0.001 |
| Lobule IV/V*,** | 3.09 ± 1.04 | −3.76 ± 1.09 | 0.87 ± 0.91 | F = 12.19, P < 0.001 |
| Lobule VI*,** | 4.93 ± 1.13 | −5.66 ± 1.25 | 1.18 ± 1.27 | F = 20.66, P < 0.001 |
| Lobule VII*,** | 3.77 ± 1.12 | −4.93 ± 1.31 | 1.45 ± 1.14 | F = 14.74, P < 0.001 |
| Lobule VIII | 2.16 ± 1.16 | −2.37 ± 1.61 | 0.04 ± 1.35 | F = 2.72, P = 0.078 |
| Lobule IX | 2.71 ± 1.41 | −2.78 ± 1.88 | −0.35 ± 1.63 | F = 2.83, P = 0.077 |
| Lobule X* | 2.50 ± 1.12 | −2.31 ± 1.34 | −0.36 ± 1.08 | F = 4.22, P = 0.018 |
| Hemisphere | ||||
| Lobule III | ||||
| L*,*** | 3.54 ± 1.04 | −3.04 ± 1.12 | −0.46 ± 1.13 | F = 9.54, P < 0.001 |
| R* | 2.90 ± 0.92 | −2.87 ± 0.98 | 0.01 ± 0.84 | F = 10.22, P < 0.001 |
| Lobule IV/V | ||||
| L*,** | 3.60 ± 0.95 | −3.69 ± 1.16 | 0.18 ± 1.14 | F = 11.86, P < 0.001 |
| R*,** | 2.83 ± 1.03 | −3.97 ± 1.31 | 1.26 ± 0.97 | F = 10.28, P < 0.001 |
| Lobule VI | ||||
| L*,** | 3.32 ± 0.96 | −3.90 ± 1.33 | 0.66 ± 1.18 | F = 10.11, P < 0.001 |
| R*,** | 2.46 ± 0.92 | −3.95 ± 1.27 | 1.55 ± 0.95 | F = 10.75, P < 0.001 |
| Crus I | ||||
| L*,** | 3.15 ± 0.81 | −3.82 ± 1.02 | 0.74 ± 0.99 | F = 14.76, P < 0.001 |
| R*,** | 2.64 ± 0.84 | −3.61 ± 1.01 | 0.96 ± 0.88 | F = 12.98, P < 0.001 |
| Crus II | ||||
| L* | 2.70 ± 0.82 | −3.09 ± 1.22 | 0.30 ± 1.15 | F = 7.66, P < 0.001 |
| R*,** | 2.50 ± 0.79 | −2.98 ± 0.95 | 0.66 ± 0.91 | F = 10.18, P < 0.001 |
| Lobule VIIB | ||||
| L* | 2.22 ± 0.94 | −2.59 ± 1.46 | 0.20 ± 1.26 | F = 3.91, P = 0.029 |
| R* | 2.23 ± 0.96 | −2.77 ± 1.24 | 0.48 ± 1.04 | F = 5.61, P < 0.001 |
| Lobule VIII | ||||
| L | 1.62 ± 1.02 | −1.61 ± 1.68 | −0.31 ± 1.37 | F = 1.40, P = 0.254 |
| R | 1.42 ± 1.06 | −1.91 ± 1.44 | 0.26 ± 1.05 | F = 1.99, P = 0.148 |
| Lobule IX | ||||
| L* | 3.04 ± 1.28 | −2.62 ± 1.58 | −0.65 ± 1.46 | F = 4.06, P = 0.027 |
| R* | 3.08 ± 1.21 | −2.68 ± 1.65 | −0.79 ± 1.21 | F = 4.51, P = 0.020 |
| Lobule X | ||||
| L* | 1.19 ± 0.52 | −0.81 ± 0.70 | −0.38 ± 0.70 | F = 4.51, P = 0.021 |
| R | 0.99 ± 0.63 | −1.14 ± 0.65 | 0.22 ± 0.70 | F = 2.79, P = 0.076 |
Age-adjusted grey matter density represents the residual from a linear regression of age over the modulated grey matter density extracted from each subregion. *Significant difference between controls and PFX+by a post hoc test (Tukey HSD). **Significant difference between PFX− and PFX+. ***Significant difference between healthy controls and PFX−. L = left; R = right.