Figure 5.
Net Ca2+ uptake into ER stores by SERCA during LTS- and bAP-evoked dendritic Δ[Ca2+]. A, Amplitudes of Δ[Ca2+] evoked by a burst of five bAPs (200 Hz) (1) or LTS (2) are not changed by ryanodine (n = 9) or CPA (n = 10), but τdecay is significantly slowed for both in the presence of the SERCA blocker compared with control (n = 11). Traces represent pooled averages of Δ[Ca2+] for each different group of cells. B, 1, Histograms summarize the effects of ryanodine (RYD) and CPA on amplitude and τdecay of Δ[Ca2+]bAP or Δ[Ca2+]5bAPs compared with control neurons (CON) (n = 18, single bAPs; n = 11, 5bAPs) in proximal dendrites. 2, As in 1 for Δ[Ca2+]LTS in proximal and distal dendrites.