Table 3.
Study | Comparison | Control Group | N | Imaging Modality |
Areas of increased activation in clinical group |
Areas of decreased activation in clinical group |
Notes |
---|---|---|---|---|---|---|---|
(126) | Attempted movement vs. rest |
None | 1 | PET | Increased activity in ACC (BA 24/32) and OFC (BA 10) |
No statistical analyses performed. Authors note an absence of motor cortex activity |
|
(127) | Resting | None | 5 | SPECT | Left Temporal and Parietal regions |
No statistical analyses performed |
|
(128) | Attempted movement vs. rest |
Healthy controls who feigned weakness |
2 | PET | Left dlPFC (BA 46) |
Qualitative between group comparison |
|
(129) | Movement vs. rest and observation of moving hand vs. observation of resting hand |
Healthy controls who moved limbs normally |
4 | fMRI | Motor cortex during movement observation (BA 4) |
No differences observed during movement itself. Qualitative comparison between groups |
|
(130) | Attempted movement vs. rest |
Healthy controls who feigned weakness |
4 | fMRI | Frontal (BA 47), striatal and lingual cortex (BA 18) |
Motor (BA 4) and OFC (BA 10/46) |
Qualitative comparison between groups |
(131, 132) |
Mental rotation of affected vs. unaffected hand |
Within subject analysis— unaffected side acts as control |
8 | fMRI | Medial frontal (BA 9/11) and superior temporal cortex (BA 22) |
Non-parametric statistical analysis performed within subjects |
|
(133) | Go NoGo Task | Healthy controls who feigned weakness |
1 | fMRI | Ventromedial frontal (BA32/10) and left orbital frontal (BA 47) |
Qualitative comparison between groups. Effects reported during movement preparation |