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. 2010 Dec;2(12):490–503. doi: 10.1002/emmm.201000102

Figure 7. Apoptotic ultrastructural changes in HD mitochondria are faster and prevented by OPA1 and blockage of DRP1.

Figure 7

  • A. Representative EM fields of neurons of the indicated genotype. Cells were cotransfected with GFP and the indicated plasmids or siRNAs, sorted and GFP-positive cells were seeded and after 18 h treated when indicated with 2 µM staurosporine for 3 h, fixed and processed for EM. Scale bar: 1 µm.
  • B-D. Morphometric analysis of cristae shape. Experiments were performed as in (A). Data represent mean ± SE of 3 independent experiments (n = 50 mitochondria from 30 different cells per each condition) and are normalized to the value in empty vector-transfected, untreated cells.