Table 1.

Selected putative transcription factor sites in p300 promoter^a

Transcription factor	Nucleotide position	Matrix simulation score	Sequence
Ets—family member ELF-2 (NERF1a)	10–26	0.910	cgaggaGGAAgaggttg
Human zinc finger protein ZNF35	12–24	0.963	aggaggAAGAggt
b zip family, induced by ER damage binds in association with NF-Y	67–81	0.945	ccgCCACggccggcc
STAT6: signal transducer and activator of transcription 6	107–125	0.963	gcgaaTTCCcgagaactcg
Ikaros 1, potential regulator of lymphocyte differentiation	112–124	0.934	tctcGGGAattcg
HMGI (Y) high-mobility group protein I (Y) factor	113–125	0.953	gcgAATTcccgag
PAX6 paired domain and homeodomain	172–190	0.900	ggcttgggcCCAGgcccgg
Myc-associated zinc finger protein (MAZ)	188–200	0.910	gtgcGAGGggccg
Gut-enriched Krueppel-like factor	203–217	0.924	agaaaaggtaAGGGc
c-Rel	264–278	0.914	aaaggaacTTCCccc
NF-kappaB	264–278	0.964	ggGGGAagttccttt
Zinc finger transcription factor ZBP-89	270–292	0.971	acttcccccaCCCCctcgggtgc
Erythroid Krueppel like factor (EKLF)	277–289	0.915	cccgaggGGGTgg
Myeloid zinc finger protein MZF1	327–333	0.985	gcGGGGa
Nuclear factor of activated T cells	368–378	0.975	cgagGAAAacc
Brn-2, POU-III protein class	391–403	0.946	cggccattttTAATtcttt

^amRNA nucleotide sequence for p300 (NM_001429) obtained from NCBI Web-based resource (http://www.ncbi.nlm.nih.gov/). Preceding from the predicted start site of p300 mRNA, 403 nucleotide sequences were analyzed using commercially available software (Genomatix: http://www.genomatix.de/) to analyze and predict transcription factor binding sites in the promoter region in the p300 gene (chromosome 22, contig-NT_01150.09, Homo sapiens chromosome 22). Base pairs in capital letters denote the core sequence used by MatInspector (Genomatix). Matrix simulation scores with great than 0.90 were selected from 66 total predicted transcription factor binding sites, based from a 1.00 core simulation score of known nucleotide sequence binding sites.