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. Author manuscript; available in PMC: 2012 Feb 15.
Published in final edited form as: Arch Biochem Biophys. 2010 Dec 9;506(2):181–187. doi: 10.1016/j.abb.2010.12.004

Figure 7.

Figure 7

Free energy plot of the logarithm of the rate constant for proton transfer kB (s−1) versus ΔpKa (pKa ZnH2O – pKa His64) determined from the RH2O/[E] pH profiles for the wild type and the mutants of HCA II containing replacements of Tyr 7 identified on the plot (♦ filled symbols); and (○) for H64A HCA II from An et al. [13] with proton transfer provided predominantly by derivatives of imidazole and pyridine acting as exogenous proton donors with the solid line a best fit of Marcus Rate Theory.