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. 2011 Jan 5;286(9):7214–7226. doi: 10.1074/jbc.M110.169342

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© 2011 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 4. — S100B up-regulates the expression of CCL3, CCL5, and CXCL12 chemokines in a RAGE-dependent manner. A, BV-2/mock microglia were treated with increasing concentrations of S100B for the indicated time, and total mRNA was extracted and subjected to real time PCR for quantification of CCL3, CCL5, and CXCL12 mRNAs. B, same as in A except that BV-2/RAGEΔcyto microglia were used. C, same as in A except that BV-2 microglia were pretreated with the indicated inhibitors, and analyses were restricted to CCL3 and CCL5. D, diaphanous-1 siRNA-treated and control BV-2 microglia were analyzed for CCL3 and CCL5 expression by real time PCR. The results are expressed as the means ± S.D. (n = 3).