TABLE 1.
Effect of Aza treatment on the lifespan of C. elegans mutants
These results represent the average of three independent experiments; p values were determined using Student's t test.
| Strain(treatment) | MLS (±S.D.) at 20 °C | Change | p value versus control | Total worms (n in three independent experiments) |
|---|---|---|---|---|
| days | % | |||
| N2(−) | 25.24 ± 0.68 | 96 (31, 32, 33) | ||
| N2(AZA) | 16.47 ± 0.49 | −34.8 | <0.001 | 98 (30, 33, 35) |
| daf-16(mu86)(−) | 18.83 ± 1.07 | 74 (24, 25, 25) | ||
| daf-16(mu86)(AZA) | 11.69 ± 0.59 | −38.0 | <0.001 | 84 (26, 29, 29) |
| mev-1(kn1)(−) | 15.96 ± 0.87 | 116 (39, 37, 40) | ||
| mev-1(kn1)(AZA) | 15.52 ± 0.66 | −2.8 | 0.56 | 133 (41, 46, 46) |
| gas-1(fc21)(−) | 20.12 ± 0.47 | 70 (20, 23, 27) | ||
| gas-1(fc21)(AZA) | 12.98 ± 0.88 | −35.5 | <0.001 | 72 (20, 22, 30) |
| daf-2(e1370) (−) | 37.23 ± 0.68 | 90 (25, 30, 34) | ||
| daf-2(e1370) (AZA) | 36.09 ± 0.69 | −3.1 | 0.65 | 68 (20, 22, 24) |