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Electrostatic molecular surface of the active cleft and the Cα main chain trace of the prosequence of the MTGase zymogen. Only the active cleft region that encompasses the prosequence is drawn here. Tyr-12 and Tyr-16 are supposed to block the acyl donor and acceptor during the cross-linking reaction. Asn-30 was used to mark the position of the long helix of the prosequence in the active cleft. The circle marks the solvent-exposed region of the catalytic triad (Cys-Asp-His).
