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. 2010 Dec 20;286(9):7348–7358. doi: 10.1074/jbc.M110.171819

FIGURE 3.

FIGURE 3.

Tlr4 deletion does not affect neutrophil levels in blood or pro-inflammatory markers in Sgpl1−/− mice. Lymphocyte and neutrophil blood numbers, pro-inflammatory cytokines in serum, and inflammatory-related markers in liver in WT (open bars), Sgpl1−/− (light gray bars), Tlr4−/− (dark gray bars), and Sgpl1−/− Tlr4−/− DKO (red bars) mice. A, blood lymphocyte and neutrophil counts were determined by the Department of Laboratory Medicine at the NIH using an automated blood cell analyzer. Results are shown as number of cells per μl of blood. The bars represent mean values, and the closed circles are individual mice. B, concentration of pro-inflammatory cytokines in serum determined using the BD CBA Array. Data are shown as mean values ± S.D., n = 9–17 mice per genotype. C, Tnf and Vcam-1 mRNA expression in liver determined using RT-qPCR. Data are shown as mean values ± S.D., n = 4 mice per genotype, all mice were analyzed at P18. *, p < 0.05; ***, p < 0.005. ns, not significant.