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. Author manuscript; available in PMC: 2011 Mar 6.
Published in final edited form as: Channels (Austin). 2010 Mar 6;4(2):108–114. doi: 10.4161/chan.4.2.11141

Figure 1.

Figure 1

Time-course for prKCNE1 modulation of KCNQ1 channels.

(A) Schematic showing injection/incubation protocol. (B) Representative current traces recorded from KCNQ1-expressing oocytes at 2, 4, 6 and 18h following prKCNE1 injection. (C) V½ values for whole-cell currents recorded from oocytes injected with KCNQ1 cRNA (open bar) and KCNQ1 cRNA and prKCNE1 (solid bars). The dashed gray line denotes the V½ obtained for KCNQ1-KCNE1 channels translated by the oocytes. (D) Time-course for prKCNE1 functional interaction with KCNQ1. In this panel, the dashed line indicates ΔV½ between KCNQ1-only and KCNQ1-KCNE1 channels translated by the oocytes. N: KCNQ1 cRNA = 9; KCNQ1 + KCNE1 cRNA = 13; KCNQ1 + prKCNE1, 2h = 3; 4h = 5; 6h = 12; 18h = 11; 24h = 8.