Table 2.
Cases in which microarray analysis did not detect aberrations identified by chromosome analysis or FISH
| Case | Karyotype | FISH | Percent Abnormal by FISH | Array Results | Size |
|---|---|---|---|---|---|
| 3 | 47,XY,+12[3]/46,XY[16]/92,XXYY[1] | nuc ish(CCND1,IGH@)x2 [202/202] | 0 | Arr(1-22)x2,(XY)x1 | |
| nuc ish(CD82,ATM)x2[199/200] | 0 | ||||
| nuc ish(pBR12,APAF1)x3 [5/200] | 2.5 | ||||
| nuc ish(D13S319,LAMP1)x2[204/204] | 0 | ||||
| nuc ish(TP53,ERBB2)x2[200/200] | 0 | ||||
| 4 | 46,XY,del(4)(p?15.2),del(11)(q21q23.3),add(14)(q32)[10]/46,XY[9] | nuc ish(ATMx1), (KAI1x2)[ 74/200] | 37.0 | del chr11:101900200-113746962 (11q22.2q23.2) | 11.8 Mb |
| nuc ish(ATMx1),(KAI1x1)[8/200] | 4.0 | ||||
| nuc ish(D13S319x1),(LAMP1x1)[31/235] | 13.2 | ||||
| nuc ish(D13S319x1),(LAMP1x2) [110/235] | 46.8 | del chr13:48903923-49406099 (13q14.3q14.3) | 502 kb | ||
| nuc ish(5'IGHVx1,3'IGHx1)[7/227] | 3.1 | ||||
| nuc ish(5'IGHVx2,3'IGHx2)(5'IGHV sep 3'IGHx1)[35/227] | 15.4 | ||||
| nuc ish(5'IGHVx1,3'IGHx2)(5'IGHV sep 3'IGHx1)[40/227] | 17.6 | ||||
| nuc ish( (TP53,ERBB2)x2[250/250] | 0 | ||||
| nuc ish(MYCx3)[ 116/200] | 58.0 | dup chr8:124436106-146015567 (8q21.13q24.3) | 21.6 Mb | ||
| del chr4:16516563-30324345 (4p15.32p15.1) | 13.8 Mb | ||||
| del chr7:81021736-96580930 (7q21.11q21.3) | 15.5 Mb | ||||
| 7 | 46,XY,t(14;19)(q32.3;q13.2)[9]/46,XY[11] | nuc ish(CD82,ATM)x2[199/200] | 0 | ||
| nuc ish(pBR12,APAF1)x2[199/200] | 0 | ||||
| nuc ish(D13S319,LAMP1)x2[243/243] | 0 | ||||
| nuc ish(CCND1,IGH@)x2[200/200] | 0 | ||||
| nuc ish(TP53x1),17cen(x2)[10/202] | 5.0 | ||||
| del chr14:105267349-106339477 (14q32.33q32.33) | 170 kb | ||||
| del chr22:21330008-21570697 (22q11.22q11.22) | 241 kb | ||||
| 8 | 46,XY,del(11)(q14q23)[4]/48,XY,+4,+inv(?18)(q21q23)[3]/46,XY[13] | nuc ish(CD82x2),(ATMx1)[21/200] | 10.5 | ||
| nuc ish(Pbr12,APAF1)x2[ 199/200] | 0 | ||||
| nuc ish(D13S319x1),(LAMP1x2)[90/201] | 44.8 | del chr13:47759453-49406099(13q14.2q14.3) | 1.6 Mb | ||
| nuc ish(CCND1,IGH@)x2[200/200] | 0 | ||||
| nuc ish(TP53,ERBB2)x2[199/200] | 0 | ||||
| dup chr4:1-191273063 | Trisomy | ||||
| dup chr18:1-76117153 | Trisomy | ||||
| 10 | 47,XY,+12[9]/46,XY[11] | nuc ish(D11Z1x2),(ATMx3)[ 11/229] | 4.8 | ||
| nuc ish(DDIT3)x3[126/226] | 55.8 | up chr12:74345-132349534 | Trisomy | ||
| nuc ish(D13S319,LAMP1)x2[199/200] | 0 | ||||
| nuc ish(CCND1,IGH@)x2[200/200] | 0 | ||||
| nuc ish(TP53x1),17cen(x2)[11/213] | 5.2 | ||||
| del chr22:21044595-21570697 (22q11.22q11.22) | 526 kb | ||||
| 16 | Previous Sideline: 47,XX,t(2;14)(p13;q32.1),+12[1]/46,XX[19] | nuc ish(pBR12,APAF1)x3[3/202] | 1.5 | Arr(1-22,X)x2 | |
| 17 | Previous Sideline: 45,XY,del(3)(q21q27),-8,del(8)(p10),add(?9) (p13),del(11)(q13q23),del(13)(q14q22),add(17)(p10)[1]/46,XY[30] | nuc ish(CD82x2),(ATMx1)[6/200] | 3.0 | del chr11:84811642-124583747 (11q14.1q24.2) | 39.8 Mb |
| nuc ish(D13S319x1),(LAMP1x2)[44/243] | 18.1 | del chr13:46386690-57242066 (13q14.2q21.1) | 10.9 Mb | ||
| nuc ish(D13S319x0),(LAMP1x1 or 2)[33/243] | 13.6 | ||||
| nuc ish(TP53x1),(ERBB2x2) [17/200] | 8.5 | ||||
| dup chr2:44073-60812692 (2p25.3p16.1) | 60.8 Mb | ||||
| del chr6:57972657-147822754 (6p11.2q24.3) | 89.9 Mb | ||||
| del chr9:9839207-27863525 (9p23p21.2) | 18.0 Mb | ||||
| 18 | 46,XY,t(3;11)(q21;p15)[,der(5)del(5)(q13q31)t(5;15)(q31;q13),r(?7)(p22q?22),der(15)t(5;15),-21[6]/46,XY[13] | nuc ish(CD82,ATM)x2[200/200] | 0 | ||
| nuc ish(pBR12,APAF1)x2[200 of 200] | 0 | ||||
| nuc ish(D13S319,LAMP1)x1[27/200] | 13.5 | ||||
| nuc ish(D13S319x1),(LAMP1x2)[82/200] | 41.0 | ||||
| nuc ish(CCND1,IGH@)x2[228/228] | 0 | ||||
| nuc ish(TP53,ERBB2)x2[195/200] | 2.5 | ||||
| del chr3:66524310-71438751 (3p14.1p14.1) | 4.9 Mb | ||||
| del chr5:67408207-67790791 (5q13.1q13.1) | 382 kb | ||||
| del chr5:76836011-180616147 (5q14.1q35.3) | 104 Mb | ||||
| del chr7:2327342-54294538 (7p22.3p11.2) | 54.2 Mb | ||||
| del chr7:81021736-96580930 (7q21.11q21.3) | 15.6 Mb | ||||
| del chr7:102955780-158788150 (7q22.1q36.3) | 55.8 Mb | ||||
| del chr21:41514980-46912065 (21q22.3q22.3) | 5.4 Mb | ||||
| 24 | 46,XY[20] | nuc ish(D11Z1,ATM)x2[213/213] | 0 | ||
| nuc ish(DDIT3)x2[229/229] | 0 | ||||
| nuc ish(D13S319,LAMP1)x1[15/203] | 7.4 | del chr13:48903923-49406099 (13q14.3q14.3) | 502.2 kb | ||
| nuc ish(D13S319x1),(LAMP1x2)[155/203] | 76.3 | ||||
| nuc ish(CCND1,IGH@)x2[223/223] | 0 | ||||
| nuc ish(TP53x2),17cen(x2)[199/200] | 0 | ||||
| 25 | N.D. | uc ish(D11Z1,ATM)x2[212/213] | 0 | Arr(1-22,X)x2 | |
| nuc ish(DDIT3)x2[204/204] | 0 | ||||
| nuc ish(D13S319x1),(LAMP1x2)[13/217] | 6.0 | ||||
| nuc ish(D13S319x0),(LAMP1x2)[30/217] | 13.8 | ||||
| nuc ish(D13S319x0),(LAMP1x2)[30/217] | 0 | ||||
| nuc ish(TP53x2),17cen(x2)[199/200] | 0 | ||||