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. 2011 Feb 25;6(2):e16799. doi: 10.1371/journal.pone.0016799

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Clones of homozygous ico alleles were generated with eyeless-Flipase in the eyes of females. Homozygous ico clones do not contain eye pigment and are white. Pigmented cells are heterozygous for ico. (A) Clones of the mutation II032 do not survive to adulthood. (B–D) Clones of the other three missense mutations exhibit a small numbers of white cells. In contrast, homozygous clones of the two null mutations develop normally (E and F), indicating that EF-G1 function is not required in the eye and that clones expressing C-terminally truncated proteins do not affect growth and patterning. The cause for the black patches of cells that can be clearly seen in G^A1, B^A18, and G^A25 but are also present in the other alleles is not entirely clear. However, their presence does not affect the interpretation of the results. See text for details.