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. 2011 Feb 25;6(2):e17252. doi: 10.1371/journal.pone.0017252

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Meng et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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E3 rats were intranasally instilled with either saline or plasmids on day 13 and 17 during the period of AIPI induction. The rats of AIPI group (n = 9) received 50 µl saline, the rats of AIPI+sR-nc (n = 9) group received 50 µg shRNA-nc plasmid and the rats of AIPI+sR-TLR3 group (n = 9) received 50 µg shRNA-TLR3 plasmid. TLR3 mRNA and cytokine mRNA expression levels in mLN were measured by QPCR (A). Levels of serum total IgE (B) and OVA-specific IgG1 (C) were measured by ELISA. Total cell numbers in BALF were counted under light microscope using a hemocytometer and values of macrophage, eosinophil and lymphocyte counts in BALF were expressed as the percentage of cell numbers of total cells (D). Results show as mean ±SEM from 9 rats in each group. *P<0.05 or **P<0.01 or ***P<0.001 denotes significance between two groups.