Table 4. Outcome of Population-based Spinal Muscular Atrophy (SMA) Screening in Taiwan.
Year (month) | 2005 | 2006 | 2007 | 2008 | 2009 (1–6) | Total |
Total Pregnancies in Taiwan* | 209,021 | 207,131 | 205,466 | 198,468 | 194,489 | 1,014,575 |
Pregnant Women in this Study | 6,395 | 17,769 | 30,335 | 34,983 | 18,129 | 107,611 |
Carriers Identified | 146 | 409 | 632 | 728 | 347 | 2,262 |
Carrier Rate of Pregnant Women | 2.28% | 2.30% | 2.08% | 2.08% | 1.91% | 2.10% |
Partners Tested | 137 | 372 | 531 | 664 | 329 | 2,038 |
Recall Rate | 93.84% | 90.95% | 84.02% | 91.21% | 94.81% | 90.10% |
Carrier Couples Identified | 4 | 8 | 12 | 16 | 7 | 47 |
Carrier Rate of Partners | 2.92% | 2.15% | 2.26% | 2.41% | 2.13% | 2.31% |
Prenatal Diagnoses | 3 | 8 | 11 | 14 | 7 | 43 |
Affected Cases | 1 | 2 | 4 | 3 | 2 | 12 |
Prevalence of SMA | 1/6,395 | 1/8,885 | 1/7,584 | 1/11,661 | 1/9,065 | 1/8,968 |
Pregnancies Terminated | 1 | 2 | 4 | 3 | 1 | 11 |
Termination Rate | 100% | 100% | 100% | 100% | 50% | 91.67% |
*Data available from the Bureau of Health Promotion, Department of Health, Taiwan (http://www.bhp.doh.gov.tw/BHPnet/Portal/).