Table 3. Meta-regression analysis of α-adducin gene G460T and GNB3 gene C825T polymorphisms with covariates of interest.
| Variables | α-adducin gene G460T | GNB3 gene C825T | ||||||
| Coef. | 95% CI | t | P | Coef. | 95% CI | t | P | |
| Model 1 | ||||||||
| Study design | 0.23 | (−0.10, 0.56) | 2.24 | 0.111 | −0.14 | (−0.34, 0.06) | −2.01 | 0.115 |
| Area | 0.21 | (−0.01, 0.43) | 3.02 | 0.057 | 0.21 | (−0.03, 0.45) | 2.41 | 0.074 |
| Diff-age | −0.16 | (−0.44, 0.11) | −1.90 | 0.154 | −0.04 | (−0.10, 0.02) | −1.74 | 0.156 |
| Diff-gender | −1.79 | (−6.49, 2.92) | −1.21 | 0.314 | −0.003 | (−0.03, 0.03) | −0.27 | 0.797 |
| Diff-BMI | −0.16 | (−0.37, 0.04) | −2.56 | 0.083 | −0.001 | (−0.18, 0.18) | −0.03 | 0.980 |
| Model 2 | ||||||||
| Study design | −0.11 | (−0.81, 0.60) | −0.49 | 0.659 | 0.02 | (−0.21, 0.24) | 0.19 | 0.859 |
| Area | 0.19 | (−0.28, 0.65) | 1.28 | 0.290 | 0.82 | (0.04, 1.59) | 2.94 | 0.043 |
| Ave-age | −0.04 | (−0.13, 0.05) | −1.29 | 0.287 | −0.01 | (−0.03, 0.18) | −0.70 | 0.522 |
| Ave-gender | 0.34 | (−2.53, 3.20) | 0.37 | 0.734 | −0.001 | (−0.02 0.02) | −0.11 | 0.919 |
| Ave-BMI | 0.06 | (−0.11, 0.23) | 1.16 | 0.330 | −0.02 | (−0.07, 0.02) | −1.28 | 0.270 |
Abbreviations: Coef., coefficient; CI, confidence interval; BMI, body mass index. Diff-age (-gender and -BMI) means the age (percent of male and BMI) differences between cases and controls (Model 1). Ave-age (-gender and -BMI) means the average age (percent of male and BMI) of both groups (Model 2).