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. 2011 Feb 25;6(2):e17269. doi: 10.1371/journal.pone.0017269

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Vernon et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Cavalieri estimator probe measurement of corpus striatum volume post-mortem in saline and lactacystin-injected animals reveals a significant decrease in the volume of the ipsilateral striatum in lesioned animals, (***p<0.01). (B) Linear regression analysis reveals a strong correlation between measurement of striatal volume in both groups from either MRI or post-mortem histology (r = . 879). (C) Cortical thickness measurements post-mortem confirms cortical thinning in the M1 and S1BF cortices of lactacystin-lesioned animals but not saline controls, consistent with MRI data. (*p<0.05; **p<0.01). (D) Linear regression also reveals a robust correlation between cortical thickness measurements in the M1 and S1BF by MRI or from post-mortem histological sections (r = . 646 and .691; respectively). Data shown in (A) and (C) are mean volume or thickness, respectively, ± SEM. Saline, N = 5, lactacystin, N = 7.