Table 1. Aromatic Amino Acids in the Catalytic Gorge of Vertebrate ChEs.

Subsite	Torpedo AChE	Oryzias AChE	Oryzias BChE	Homo BChE
Peripheral Site	Tyr70	Phe72	Met69	Asn68
	Tyr121	Tyr124	Val124	Gln119
	Trp279	Trp282	Tyr282	Ala277
Hydrophobic Patch1	Trp84	Trp86	Trp83	Trp82
	Tyr130	Tyr133	Tyr133	Tyr128
	Phe330	Phe333	Cys333	Ala328
	Phe331	Phe334	Phe334	Phe329
Acyl Pocket	Phe288	Phe291	Leu291	Leu286
	Phe290	Phe293	Phe293	Val288
Wall of Gorge	Trp114	Trp117	Trp119	Trp114
	Trp233	Trp236	Trp236	Trp231
	Tyr334	Tyr337	Tyr337	Tyr332
	Trp432	Trp453	Trp435	Trp430
	Tyr442	Tyr463	Tyr445	Tyr440

Conserved aromatic residues are shown in bold. Torpedo AChE is representative

of all vertebrate AChEs and Homo BChE is representative of all vertebrate BChEs.

¹Includes the choline-binding site.