Table 2. Amino Acid Sequences in the Region of the Acyl Pocket of Vertebrate AChE and BChE.^a .

Enzyme	Class	Species	Sequenceb
			288 290 400
AChE	Mammalia	Felis catus	VFRFSFVPVV…DHNVVCP
		Bos taurus	VFRFSFVPVV…DHNVVCP
		Oryctolagus cuniculus	LFRFSFVPVV…DHNVVCP
		Homo sapiens	VFTFSFVPVV…DHNVVCP
	Aves	Gallus gallus	VFRFAFVPVV…DHNVVCP
	Reptilia	Bungarus fasciatus	IFRFPFVPVI…DHNVICP
	Amphibia	Xenopus tropicalis	VFRFAFVPVP…DHNVICP
	Osteichthyes	Electrophorus electricus	LFRFSFVPVI…DHNVICP
		Danio rerio	LFRFSFVPVV…DQNVICP
		Oryzias latipes	LFRFSFVPVV…DHNVICP
	Chondrichthyes	Torpedo spp.	IFRFSFVPVI…DHNVICP
	Agnatha	Myxine glutinosa	IFRFPFVPVV…DINVICP
BChE	Mammalia	Felis catus	LLSVNFGPVV…DYNIICP
		Bos taurus	LLSVNFGPTV…DYNIICP
		Oryctolagus cuniculus	LLNFPFGPTV…DYNFICP
		Homo sapiens	PLSVNFGPTV…DYNFICP
	Aves	Gallus gallus	LLHIYFCPTV…DYHIICP
	Amphibia	Xenopus tropicalis	IIEMTFPPSV…DYNFICP
		Xenopus tropicalis	VIEVNFPPTV…DYNFICP
	Osteichthyes	Gasterosteus aculeatus	IIITPFVPYV…DQYFVCP
		Fugu rubripes	LGGYPFVPVV…DVLFVCP
		Oryzias latipes	LLNFPFGPTV…DQMFVCP

^aGenBank accession numbers (unless otherwise noted) are for AChE: F. catus (AF053485), B. taurus (AF061813) O. cuniculus (U05036), H. sapiens (AK223443), G. gallus (U03472), B. fasciatus (U54591), X. tropicalis (ENSEMBL: ENSXETG00000017226), E. electricus (AF030422), Danio rerio (AJ251640), O. latipes (DK110600) Torpedo spp. (X03439, X05497), M. glutinosa (U55003). For BChE: F. catus (AF053483), B. taurus (M62410), O. cuniculus (X52090), H. sapiens (M16541), G. gallus (AJ306928), X. tropicalis (EG655516, CX359666), G. aculeatus (ENSEMBL: ENSGACG00000007230), F. rubripes (EMBL CAAB01000000), O. latipes (AV668390). Conserved Phe residues of acyl pockets in bold; conserved Phe residue of BChE implicated in aromatic trapping is underlined.

^bNumbering of acyl pocket residues: Phe288, Phe290, and Val400 in Torpedo spp. AChE. Conserved Phe (F) residues of acyl pockets in bold; conserved Phe residue of BChE implicated in aromatic trapping is underlined.