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. 1987 Apr;84(7):1891–1895. doi: 10.1073/pnas.84.7.1891

Nesting: hierarchies of allosteric interactions.

C H Robert, H Decker, B Richey, S J Gill, J Wyman
PMCID: PMC304547  PMID: 3470764

Abstract

A generalization of the allosteric model is presented that incorporates a hierarchy of conformational equilibria. Such a formulation draws upon structural organization already seen in many large macromolecular systems. The functional binding properties of the macromolecule reflect conformational equilibria at each structural level. Appropriate "nested" models are used to interpret structural features and functional aspects of two hemocyanin systems with a large number (12 and 24) of binding sites.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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