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. 2010 Oct;32(10):885–893. doi: 10.1002/bies.201000037

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Copyright © 2010 WILEY Periodicals, Inc.

Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.

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Transcripts and protein isoforms of C/EBPα and β transcription factors. Three N-terminally distinct protein isoforms (colored bars) are translated from subsequent in-frame initiation codons (black arrows) within the C/EBPα and β transcripts (open bars). Small uORFs (blue) preceding the initiation codons of C/EBPα-p42 and C/EBPβ-LAP regulate the balanced expression of long and truncated protein isoforms. The C/EBPα and β isoforms contain N-terminal trans-activating (green) and regulatory (red) domains, as well as highly conserved C-terminal basic (orange) and leucine zipper (purple) domains. The positions and sizes of indicated domains are derived from published data ³²^,⁸⁸^–⁹¹. C/EBP, CCAAT enhancer binding protein; ext, extended; LAP, liver activating protein; LIP, liver inhibitory protein.