Table 2.
Characteristics of the covariate-free model
| Population mean | Inter-patient variability | Inter-occasion variability | ||||
|---|---|---|---|---|---|---|
| Parameter | Estimate | SE | Estimate | 95% CI | Estimate | 95% CI |
| Ktr (h−1) | 5.47 | 0.64 | 28% | 0–41 | 30% | 21–36 |
| Q/F (l h−1) | 57.6 | 3.1 | 57% | 33–73 | ||
| Vc/F (l) | 238 | 5 | 47% | 0–74 | 79% | 62–89 |
| Vp/F (l) | 500 (Fixed) | – | – | – | ||
| CL/F (l h−1) | 24.1 | 1.3 | 36% | 21–46 | 35% | 26–43 |
Objective function 6564 (proportional error = 9.74%; additive error = 1.36 ng ml−1); CI is confidence interval, SE is standard error, Ktr is the absorption rate, F is oral bioavailability, CL is clearance, Q is inter-compartmental clearance, Vc is the central volume of distribution and Vp is the peripheral volume of distribution,