Table 5.
Relative bias and precision for the 0, 1, 3 h sampling schedule as a function of formulation, period post-graft and CYP3A5 status
| Group | Mean bias | Bias SE | Median bias | Range | RMSE | Number outside ±20% |
|---|---|---|---|---|---|---|
| Advagraf® | −3.6% | 7.6% | −4.1% | −17.7–14.3% | 8.2% | 0/14 |
| Prograf® | 1.3% | 8.5% | 0.5% | −20.0–21.5% | 8.5% | 1/44 |
| Early period (day 7 to day 14) | 1.1% | 10.6% | −0.2% | −20.0–21.5% | 10.3% | 1/18 |
| Stable period (≥1 month) | −0.3% | 7.5% | 0.3% | −17.7–18.7% | 7.4% | 0/40 |
| CYP expressors | 1.8% | 8.4% | 2.3% | −9.1–11.6% | 7.7% | 0/5 |
| CYP non-expressors | 0.0% | 8.7% | 0.1% | −20–21.5% | 8.6% | 1/53 |
SE is standard error, RMSE is root mean squared prediction error, CYP is cytochrome P450 3A5.