Table 6.

Observed LY2181308 plasma pharmacokinetic data in cancer patients

		Observations (mean (CV %)) Day 3
Dose(mg)	n*	Cmax (ng ml−1)	AUC (0,24 h)(ng ml−1 h)
100	1	7 060	27 161
200	1	12 815	69 733
400	4	31 370 (23.6)	152 637 (21.1)
600	3	45 654 (13.1)	211 467 (23.9)
750	24	69 120 (34.2) 39 923–155 514†	342 794 (31.5) 187 344–603 944†
900	1§	86 787	251 031
1 000	1‡	84 037	425 279

^*Number of patients.

^†Range.

^‡Following a 4 h infusion, instead of 3 h, in order to prevent peak related toxicity.

^§On day 3, this patient was dosed over 1.17 h instead of the 4 h prescribed for the higher doses.