Figure 3.
Mean levels of DPP-4 inhibition in the plasma of young, healthy, fasted, male Japanese subjects (except as noted) given single oral doses of sitagliptin. The values in (A) were not corrected for dilution of plasma samples during the assay procedure. The values in (B) were corrected for this artifact following a previously described statistical procedure [14]. Japanese subjects received either placebo (
and 
in panels A and B) or doses of 5 (
), 12.5 (
), 25 (
), 50 (
), 100 (
), 200 (
) and 400 (
) mg sitagliptin. Historical data are included from young, healthy, fasted, non-Japanese male subjects given single oral doses of 50 (
) and 100 (
) mg sitagliptin