Table 1.

Mean values (± SD), coefficient of variation (CV%) and ranges of the main pharmacokinetic parameters

	Mean (±SD)	CV%	Range
GEMend (mg l−1)	21.6 ± 5.6	25.9	9.7–35.6
MR	1.85 ± 0.53	28.6	0.76–4.2
AUC(0,∞) (mg l−1 h)	10.8 ± 3.2	29.6	4.8–19.3
CL (l h−1 m−2)	105.9 ± 28.3	26.7	55.3–209.8
Vz (l m2−1)	37.0 ± 30.4	82.2	10.0–129.3