Table 1.

Human alternatively spliced proteins in Swissprot with minimum two isoforms in PDB (FGFR2_HUMAN has three isoforms in PDB)

Swissprot ID	Isoform numbers	PDB ID1	PDB ID2	Alt splic type	Difference	Description
CHKA_HUMAN	Isoforms 1,2	3f2r_A	2cko_A	Insertion*	18	Longer isoform 3f2r has an insertion of 18 amino acids disordered in the longer variant. In 2cko, 7 residues around the site of insertion are also disordered
CRK_HUMAN	Isoforms 1,2	2eyz_A	2eyy_A	C-term + domain	96	Longer isoform 2eyz has three SH3 domains whereas shorter 2eyy has only two. The shorter version is oncogenic
CSF3_HUMAN	Isoforms 1,2	1gnc_A	1pgr_A	Insertion*	3	Longer isoform 1gnc_A has a 3 amino acid insertion, missing from structure (i.e. disordered)
EDA_HUMAN	Isoforms 1,3	1rj7_A	1rj8_A	Insertion	2	1rj7_A has a 2-amino-acid insertion compared to 1rj8_A, structure determined. Distinct receptor specificities
FGFR2_HUMAN	Isoforms 19,14	1nun_B	3dar_A	C-term + domain	120	1nun_B consists of two Ig-like domains, 3dar_A has only one
FGFR2_HUMAN	Isoforms 1,19	1djs_A	1nun_B	Insertion	2	1djs_A has a 2-amino-acid insertion compared to 1nun_B, both structured
GHR_HUMAN	Isoforms 1,4	1axi_B	2aew_A	Insertion*	27	1axi_B is 27-amino-acid longer in N-terminus, disordered
GNAS2_HUMAN	Isoforms 1,2	1azs_C	1cul_C	Insertion*	14	1azs_C has a 14-amino-acid insertion compared to 1cul_C, disordered; 1 cul_C has 5-amino-acid disordered around the place of insertion
KHK_HUMAN	Isoforms 1,2	2hqq_A	3b3l_A	Alt exon	44	Same length substitution (alternative exons), both structures are fully ordered
MK08_HUMAN	Isoforms 1,3	3elj_A	1ukh_A	Alt exon	12	Same length substitution (alternative exons), both structures are fully ordered
NRX1A_HUMAN	Isoforms 1,2	2r1b_A	3bod_A	Insertion*	30	2r1b_A has a 30-amino-acid insertion, half of it is ordered and forms a protruding-long helix
PTN13_HUMAN	Isoforms 1,4	1q7x_A	3pdz_A	Insertion	5	1q7x_A has a 5-amino-acid insertion, fully ordered; they have a different affinity to tumor suppressor protein APC
RAC1_HUMAN	Isoforms 1,2	1ryf_A	1i4t_D	Insertion*	19	1ryf_A has a 19-amino-acid insertion, disordered, also in the preceeding 15 amino acids; the insertion induces a conformational change, PMID:14625275
ST2B1_HUMAN	Isoforms 1,2	1q1z_A	1q1q_A	Alt N-term	10	1q1q_A and 1q1z_A both form helical structures in their N-termini upon pregnenolone binding, have different specificity
UAP1_HUMAN	Isoforms 1,2	1jvd_A	1jv1_A	Insertion*	17	1jvd_A has a 17-amino-acid insertion, fully disordered. 1jv1_A is structured at the place of insertion

The isoform numbers and the PDB identifiers representing the two isoforms are listed. The type of AS and the number of residues the two PDBs differ from each other (Difference) are indicated. Asterisk next to the number shows if intrinsic disorder was also observed in one or both isoforms.