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. Author manuscript; available in PMC: 2011 Feb 26.
Published in final edited form as: J Med Chem. 2010 Oct 14;53(19):6867–6888. doi: 10.1021/jm1001748

Table 6.

Enzyme Inhibition Data of FTIs Exhibiting a Range of Ethylenediamine-Analogue Scaffolds

graphic file with name nihms-268901-t0057.jpg
Compound IC50 (nM) Selectivity
Number R4 hFTase GGTase-I
1a graphic file with name nihms-268901-t0058.jpg 56 ± 29 2700 ± 2200 48
20a graphic file with name nihms-268901-t0059.jpg 420 ± 210 4600 (n = 2) 11
20b graphic file with name nihms-268901-t0060.jpg 1000 ± 350 >10,000 >10
20c graphic file with name nihms-268901-t0061.jpg 450 ± 70 9150 (n = 2) 20
20d graphic file with name nihms-268901-t0062.jpg 650 ± 220 >10,000 >15
20e graphic file with name nihms-268901-t0063.jpg 380 ± 100 7050 (n = 2) 19