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. Author manuscript; available in PMC: 2012 Mar 4.
Published in final edited form as: Org Lett. 2011 Jan 26;13(5):1118–1121. doi: 10.1021/ol103149b

Table 1.

Synthesis of Penta-substituted Pyrroles A

graphic file with name nihms268343u2.jpg
Pyrrole Ar R1 R2 E yield %
A1 Ph 4-O2N-Ph 4-Cl-Ph CN 81
A2 Ph 2,4,6-i-Pr-Ph 3,4,5-MeO-Ph CN 91
A3 Ph 4-MeO-Ph 3,4,5-MeO-Ph CN 89
A4 4-MeO-Ph 4-MeO-Ph 3-Br-4,5-MeO-Ph CN 78
A5 Ph Me 3-Br-4-MeO-Ph CN 37
A6 Ph 4-MeO-Ph 3,5-Br-Ph CN 56
A7 Ph 4-MeO-Ph graphic file with name nihms268343t1.jpg CN 41
A8 Ph 4-MeO-Ph 2,6-Cl-Ph CN 78
A9 Ph 4-F-Ph 2,6-Cl-Ph CN 55
A10 Ph Bu 4-O2N-Ph CN 71
A11 Ph 4-Me-Ph Pr CN 55
A12 Ph Me graphic file with name nihms268343t2.jpg CN 50
A13 Ph graphic file with name nihms268343t3.jpg 4-MeOOC-Ph CN 96
A14 Ph Me 2-Cl-6-F-Ph CN 88
A15 Ph Me 2,6-Cl-Ph CN 65
A16a Ph 4-MeO-Ph 4-Br-Ph CONH2 38
A17a Ph 4-MeO-Ph 3,4,5-MeO-Ph COOEt 76
a

The intermediate pyrrolines were obtained in EtOH.