Table 3.
EC50 Values of 1 – 14, M-1 – M-4, and A-1 – A-3 on the Proliferation/Viability of Human Breast Tumor T47D and Prostate Tumor PC-3 Cells in a 48 h Exposure Concentration-Response Study.
| compound | T47D | PC-3 | ||
|---|---|---|---|---|
| EC50 μM | (95% CI) μM | EC50 μM | (95% CI) μM | |
| 1 | 1.36 | (1.19 – 1.54) | 2.09 | (1.91 – 2.28) |
| 2 | 0.91 | (0.79 – 1.06) | 1.14 | (1.01 – 1.29) |
| 3 | 3.13 | (2.81 – 3.49) | 3.36 | (3.06 – 3.68) |
| 4 | 3.57 | (3.14 – 4.07) | 4.18 | (3.52 – 4.96) |
| 5 | 1.36 | (1.18 – 1.57) | 1.88 | (1.66 – 2.13) |
| 6 | 1.56 | (1.31 – 1.85) | 2.19 | (1.44 – 3.33) |
| 7 | 3.62 | (3.11 – 4.23) | 7.03 | (5.91 – 8.37) |
| 8 | 5.52 | (5.20 – 5.85) | 10.5 | (8.92 – 12.5) |
| 9 | 1.32 | (1.19 – 1.46) | 2.27 | (1.89 – 2.71) |
| 10 | 3.22 | (2.85 – 3.63) | 6.05 | (5.10 – 7.18) |
| 11 | 4.28 | (3.95 – 4.62) | 5.31 | (4.94 – 5.71) |
| 12 | 2.88 | (2.61 – 3.19) | 3.82 | (3.50 – 4.16) |
| 13 | 1.57 | (1.40 – 1.76) | 2.18 | (2.04 – 2.33) |
| 14 | 4.01 | (3.73 – 4.31) | 5.26 | (4.91 – 5.65) |
| M-1 | 6.95 | (6.28 – 7.68) | > 20 | N/A |
| M-2 | 4.67 | (4.31 – 5.06) | > 20 | N/A |
| M-3 | 4.54 | (4.08 – 5.05) | 6.41 | (5.39 – 7.62) |
| M-4 | 6.18 | (5.84 – 6.54) | 10.6 | (9.37 – 11.9) |
| A-1 | 4.72 | (4.17 – 5.35) | 6.41 | (5.02 – 8.17) |
| A-2 | 0.73 | (0.62 – 0.85) | 1.17 | (1.03 – 1.32) |
| A-3 | 0.97 | (0.85 – 1.11) | 1.16 | (0.98 – 1.37) |
| 15 | 0.28 | (0.23 – 0.34) | 0.98 | (0.93 – 1.04) |
The EC50 and 95% CI values were determined from one experiment performed in triplicate. For comparison purpose, the maximum inhibition was set at 50% for T47D and 40% for PC-3 cells.