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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Neurobiol Learn Mem. 2010 Nov 23;95(2):134–144. doi: 10.1016/j.nlm.2010.11.003

Figure 11.

Figure 11

Progesterone Concentration, LTP, LTD and IPSC recordings

(A) Vehicle and P4 at different concentrations (10−9, 10−8, 10−7, and 10−6 M) was compared with fEPSP values during the baseline synaptic transmission (BST), LTP and LTD periods. At the 2 highest concentrations tested, P4 attenuated BST and LTP, but had no effect on LTD.

(B) Using intracellular recordings of inhibitiory post-synaptic currents (IPSCs) from individual CA1 pyramidal neurons, P4 at 10−6 M increased GABAA receptor-mediated current in two of five recorded cells. The currents were recorded with sharp electrodes in discontinuous single electrode volgage clamp mode. Representative current traces recorded before and during P4 application at 10−6 M. Reprinted with permission from (Foy et al., 2008a). Copyright 2010 Cold Spring Harbor Laboratory Press.