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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: Pain. 2010 Dec 13;152(3 Suppl):S49–S64. doi: 10.1016/j.pain.2010.11.010

Figure 11.

Figure 11

Brain regional grey matter decreases in a number of chronic pain conditions. A. Bilateral dorsolateral prefrontal cortex and unilateral thalamic grey matter decreases in chronic back pain, from [8]. B. Insula and cingulate cortex grey matter decreases in irritable bowel syndrome, from [27]. Multiple brain regions show decrease grey matter density in C. fibromyalgia, from [58], and in D. tension headache, from [93]. The illustrated data are the earliest reports of brain morphological changes in various pain conditions. The list of additional pain conditions impacting brain anatomy is expanding very quickly.