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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: Pain. 2010 Dec 13;152(3 Suppl):S49–S64. doi: 10.1016/j.pain.2010.11.010

Figure 12.

Figure 12

Evidence for brain grey matter density recovery with cessation of chronic pain. A: Left panel shows brain regions decreased in grey matter density in chronic osteoarthritis patients. Right panel shows brain regions where grey matter density increases following joint replacement and cessation of pain in osteoarthritis patients. Generally similar brain regions seem to changes with the presence and cessation of chronic pain. Adapted from [89]. B: Brain regional morphometry changes in post-traumatic headache. Grey matter density changes are shown for two brain regions in patients that develop chronic pain (3 months) and one year later when the pain subsided (1 year). In both areas grey matter signal recovers to original levels when pain symptoms subside. Adapted from [80].