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Rebamipide suppressed TBK1-IRF3/7-IFN-α/β signaling pathway in DSS mice. Effect of rebamipide on TLR-TBK1 signaling pathway in colon specimens from mice given oral DDS examined by real-time RT-PCR of TBK1, IRF3, IRF7, IFN-α and IFN-β. Messenger RNA expression of these genes was increased because of colonic inflammation in DSS mice, but this increase was suppressed in DSS mice given daily rectal rebamipide.
