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Rebamipide suppressed TLR4-TBK1 signaling pathway in human colonic epithelial cells. Lipopolysaccharide (TLR4 ligand) was added to CaCo2 colonic epithelial cells with or without rebamipide. LPS alone increased, whereas LPS plus rebamipide suppressed mRNA expression of all of these genes to control levels in CaCo2 cells.
