Fig. 1.

Hepatic HO-1 expression and its activity in the absence of Bach1. (A) Wild type mice (open bar) and Bach1^−/− mice (closed bar) were fed either regular chow or MCD diet for 8 w prior to quantification of hepatic expression of HO-1 mRNA by real-time PCR (n = 5/each group). (B) HO-1 activity in the liver from wild type (WT) or Bach1^−/− (KO) mice were determined with standardlized of protein concentration (n = 5/each group). ZnPP was utilized as a HO-1 inhibitor for negative control. *p<0.05, wild type vs Bach1^−/− mice.