Figure 3.
Expression patterns of c-myc, p27, p21, cyclin d1 and cyclin e are similar in TEBs of wild-type, Brca1f/f;MMTV-Cre and Brca1f/f;MMTV-Cr/p53+/− mice. Immunohistochemical staining of c-myc (a–c), p21 (d–f), p27 (g–i), cyclin d1 (j–l) and cyclin e (m–o) in TEBs of 6-week-old wild-type (a, d, g, j and m), Brca1f/f;MMTV-Cre (b, e, h, k and n) and Brca1f/f;MMTV-Cre P53+/− (c, f, i, l and o) mice. Arrows indicate nuclear-localized c-myc, p21, p27, cyclin d1 or cyclin e expression. Large images, × 20; small insets, × 40. Medium insets are cross sections, × 20; scale bars, 20 µm.