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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: Curr Opin HIV AIDS. 2011 Jan;6(1):43–48. doi: 10.1097/COH.0b013e32834086b3

Figure 2. Model of HIV-1 infection in HPCs.

Figure 2

Multipotent HPCs can become infected with HIV-1, leading either to active infection, cell death, and virion release, or to latent infection. Latently infected HPCs with self-renewal capacity will then continue to self-renew, generating an expanded reservoir of latent HIV-1 in these cells. If the host cell is stimulated to differentiate, the latent virus reactivates, leading to cell death and virion release.