Table 2.
 Multivariate Cox regression analysis of some measures of disease status and important treatment modalities at time of entry to cohort. Values are numbers (percentages) unless stated otherwise
| Variable | Alive (n=65) | Dead (n=211) | Univariate model | Multivariate model* | |||
|---|---|---|---|---|---|---|---|
| Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | ||||
| Mean (SD) age (years) | 26.7 (7.5) | 25.6 (8.1) | 0.98 (0.97 to 1.00) | 0.07 | 0.99 (0.97 to 1.01) | 0.54 | |
| Male sex | 46 (71) | 101 (48) | 0.74 (0.57 to 0.98) | 0.03 | 0.89 (0.66 to 1.18) | 0.41 | |
| Body mass index <19 | 35/63 (56) | 144/208 (69) | 1.70 (1.26 to 2.29) | <0.001 | 1.52 (1.10 to 2.10) | 0.011 | |
| Pancreatic insufficiency | 56/65 (86) | 197/209 (94) | 1.63 (0.91 to 2.92) | 0.10 | 0.91 (0.46 to 1.80) | 0.79 | |
| Chronic Pseudomonas aeruginosa infection | 39/61 (64) | 189/209 (90) | 2.16 (1.39 to 3.37) | 0.001 | 1.18 (0.79 to 1.76) | 0.41 | |
| Cystic fibrosis related diabetes | 10/64 (16) | 62 (29) | 1.58 (1.78 to 2.13) | 0.003 | 1.28 (0.92 to 1.79) | 0.14 | |
| Use of recombinant human DNase | 50 (77) | 111 (53) | 0.57 (0.44 to 0.75) | <0.001 | 0.59 (0.44 to 0.79) | <0.001 | |
| Use of nebulised antibiotics | 43/60 (72) | 177/211 (84) | 2.22(1.40 to 3.54) | 0.001 | 1.84 (1.05 to 3.22) | 0.033 | |
| Use of long term oxygen therapy | 2/62 (3) | 60/207 (29) | 4.47 (3.27 to 6.16) | <0.001 | 3.52 (2.49 to 4.99) | <0.001 | |
*Includes all variables listed in table.