Table 5.
List of the human genes in the INHGI with the 10 highest druggability scores
| Gene | Druggability score | (Median [min,max])1 | N | W | Wc2 (two-tailed p = 0.05) | Druggability evidence3 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Normal | Shuffled | |||||||||||||
| HLA-F | 0.887[0.803,0.915] | 0.530[0.427,0.584] | 10 | 0 | 8* | No evidence | ||||||||
| PLAU4 | 0.886[0.808,0.907] | 0.561[0.387,0.675] | 10 | 0 | 8* | 19301652 | ||||||||
| CD8A4 | 0.885[0.871,0.902] | 0.56[0.37,0.664] | 10 | 0 | 8* | No evidence | ||||||||
| CD194 | 0.880[0.751,0.907] | 0.562[0.38,0.628] | 10 | 0 | 8* | 19509168 | ||||||||
| ITGAM4 | 0.878[0.614,0.887] | 0.534[0.36,0.656] | 10 | 1 | 8* | 11931348 | ||||||||
| THBS15 | 0.875[0.53,0.9] | 0.532[0.293,0.592] | 10 | 0 | 8* | 17878288 | ||||||||
| ITGAX | 0.873[0.784,0.897] | 0.539[0.422,0.691] | 10 | 0 | 8* | No evidence | ||||||||
| CXCR5 | 0.871[0.755,0.895] | 0.537[0.49,0.59] | 10 | 0 | 8* | 17652619 | ||||||||
| EBI3 | 0.871[0.801,0.888] | 0.529[0.391,0.626] | 10 | 0 | 8* | 19556516 | ||||||||
| IL64 | 0.87[0.766,0.893] | 0.591[0.361,0.643] | 10 | 0 | 8* | 17465721 | ||||||||
| TIMP25 | 0.869[0.645,0.916] | 0.584[0.34,0.701] | 10 | 0 | 8* | 10985804 | ||||||||
1 Of 10 scores
2 According to table of critical values for W in [6]
3 Pudmed IDs of most recent articles clearly stating that such genes may be drug target candidates
4 Morbid genes according to Morbid Map [46]
5 Genes among those with 10 highest morbidity scores (Table 4)
* Difference statistically significant