Skip to main content
. Author manuscript; available in PMC: 2011 Feb 28.
Published in final edited form as: Ann Neurol. 2009 Jan;65(1):67–75. doi: 10.1002/ana.21536

Fig 4.

Fig 4

Effect of rEV576 on IgG subclasses in experimentally acquired myasthenia gravis (EAMG). Rat serum from treated and untreated EAMG rats was collected at the end of treatment (6 weeks after immunization). The level of individual IgG subclasses was measured by enzyme-linked immunosorbent assay (ELISA). There were no significant differences in total IgG and IgG2a subclasses in severe (S-EAMG) or mild EAMG (M-EAMG) (not shown). M-EAMG rats treated with rEV576 showed a decreased level of complement-fixing IgG1 (p > 0.001). Results are shown in picograms per milliliter (pg/ml; n = 6 rats per group). Bars indicate ± standard error of the mean of triplicate ELISA determinations with sera from individual rats. Gray bars represent M-EAMG; white bars represent M-EAMG + rEV576.